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If you’re the kind of person who likes to hit the gym with a coffee in one hand and a shaker bottle in the other, you’ve probably wondered: Can you combine creatine and caffeine? Is it genius—or just a waste?

Some fitness influencers swear by mixing creatine into their morning brew for a double hit of energy and performance. Others claim caffeine cancels out creatine’s benefits, especially when it comes to muscle growth and strength. So what’s the truth? Is this combo the ultimate fitness cheat code, or a scientifically shaky Instagram trend?

Let’s stir the pot—literally—and dig into what really happens when you pair caffeine with creatine.

Two power players, one mug
On their own, both caffeine and creatine have impressive credentials.

Caffeine is the world’s most popular stimulant—and for good reason. It blocks adenosine receptors in your brain, making you feel more alert and less tired. It also increases adrenaline and improves athletic performance, especially in short bursts of high-intensity exercise. Translation: you're more likely to push harder in your HIIT class or hit a PR on squats.

Creatine, on the other hand, isn’t about hype—it’s about horsepower. It works by increasing phosphocreatine stores in your muscles, allowing you to produce more ATP (your body’s main energy molecule) during intense workouts. The result? More power, faster recovery, and better muscle gains over time.

So, in theory, combining the mental jolt of caffeine with the muscular boost of creatine should make for a match made in workout heaven. Right?

The 90s debate that won’t die
This creatine-vs-caffeine debate actually dates back to a small 1996 that’s haunted gym culture for decades.

In that study, participants who took creatine plus caffeine didn’t see the same strength improvements as those who took creatine alone. That was enough for people to sound the alarm: caffeine interferes with creatine, don’t take them together.

But here’s the catch—the study was tiny (only 9 participants), short (3 days), and involved a very specific timing and dosing protocol. Despite that, it somehow became a creatine gospel.

Fast forward to today, and the research landscape looks very different.

Recent studies suggest there’s no significant clash between the two—at least, not for most people. A 2017 published in Journal of the International Society of Sports Nutrition concluded there’s insufficient evidence to say caffeine ruins creatine’s effects. In fact, many athletes use both with zero problems.

Timing might be the issue, not the ingredientsThe confusion may not be about what you’re taking, but when you’re taking it.

Creatine works best when taken daily and allowed to build up in your system over time. Caffeine, on the other hand, works almost immediately and wears off in a few hours.

So if you’re downing both five minutes before your workout and expecting instant magic, you might be disappointed. But if you take creatine consistently—whether in coffee, juice, or plain water—you’re giving it the long runway it needs to work.

Some experts also think the issue might be related to gastrointestinal discomfort. Taking creatine with a large dose of caffeine (especially in a fasted state) could irritate your gut or cause cramps during training. That’s more about individual tolerance than molecular warfare.

Should you actually mix creatine into your coffee?
From a chemistry standpoint, creatine monohydrate is stable in warm temperatures for a reasonable amount of time—so pouring it into hot coffee isn’t going to destroy it instantly. Just don’t leave it sitting in boiling water for an hour and expect results.

Some people say they don’t love the texture—creatine doesn’t fully dissolve, so you might end up with a grainy bottom-sip unless you stir well or blend it. But functionally? It works.

Also, some anecdotal reports suggest caffeine might slightly increase creatine’s absorption by stimulating blood flow, though this isn’t well-established in peer-reviewed research.

If you enjoy coffee and you’re already using creatine regularly, there’s no harm in combining them—just don’t expect an overnight superpower spike.

When it might backfire
There are a few cases where this combo isn’t ideal.

If you’re prone to anxiety, jitters, or insomnia, adding creatine to your morning cup could be fine—but doubling down with a pre-workout mix that contains more caffeine later in the day might be too much. Overdoing caffeine can spike cortisol and mess with recovery.